Sequence Detail

ID/Version

P49698 A2A5I5 A2ICH0 Q3UNX3 Q8CFY1 (UniProt | EBI)

Last sequence update: 2007-05-29
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Hepatocyte nuclear factor 4-alpha; Short=HNF-4-alpha;AltName: Full=Nuclear receptor subfamily 2 group A member 1;AltName: Full=Transcription factor 14; Short=TCF-14;AltName: Full=Transcription factor HNF-4;

Provider

SWISS-PROT

Sequence

Polypeptide 474 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hnf4a	hepatic nuclear factor 4, alpha	109	214	3	27

Sequence references in MGI

J:22110 Hata S, et al., Identification of two splice isoforms of mRNA for mouse hepatocyte nuclear factor 4 (HNF-4). Biochim Biophys Acta. 1995 Jan 2;1260(1):55-61
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:111441 Farber CR, et al., Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains. BMC Genomics. 2006;7:102
J:134163 Pearson ER, et al., Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene. PLoS Med. 2007 Apr;4(4):e118
J:156994 Schmutz I, et al., The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev. 2010 Feb 15;24(4):345-57
J:244975 Kriebs A, et al., Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8776-8781
J:271712 Zhang T, et al., Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity. Theranostics. 2018;8(19):5246-5258
J:283180 Qu M, et al., Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12305-E12312
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89