Sequence Detail

ID/Version

P50172 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=11-beta-hydroxysteroid dehydrogenase 1 {ECO:0000303|PubMed:7873449}; Short=11-DH; Short=11-beta-HSD1 {ECO:0000303|PubMed:7873449}; EC=1.1.1.146 {ECO:0000269|PubMed:23415904, ECO:0000269|PubMed:30902677};AltName: Full=

Provider

SWISS-PROT

Sequence

Polypeptide 292 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hsd11b1	hydroxysteroid 11-beta dehydrogenase 1	25	101	4	20

Sequence references in MGI

J:23036 Oppermann UC, et al., Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase. Eur J Biochem. 1995 Jan 15;227(1-2):202-8
J:23591 Rajan V, et al., Cloning, sequencing and tissue-distribution of mouse 11 beta-hydroxysteroid dehydrogenase-1 cDNA. J Steroid Biochem Mol Biol. 1995 Feb;52(2):141-7
J:37988 Voice MW, et al., The sequence of 5' flanking DNA from the mouse 11 beta-hydroxysteroid dehydrogenase type 1 gene and analysis of putative transcription factor binding sites. Gene. 1996 Nov 28;181(1-2):233-5
J:45085 Kotelevtsev Y, et al., 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14924-9
J:199550 Mitic T, et al., 11beta-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo. Biochem Pharmacol. 2013 Jul 1;86(1):146-53
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89