Sequence Detail

ID/Version

P51450 Q91YT5 Q9QXD9 Q61027 Q9R177 E9Q8I1 Q3U513 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Nuclear receptor ROR-gamma;AltName: Full=Nuclear receptor RZR-gamma;AltName: Full=Nuclear receptor subfamily 1 group F member 3;AltName: Full=RAR-related orphan receptor C;AltName: Full=Retinoid-related orphan receptor-gamma;AltName: Full=Th

Provider

SWISS-PROT

Sequence

Polypeptide 516 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rorc	RAR-related orphan receptor gamma	56	112	5	31

Sequence references in MGI

J:30013 Ortiz MA, et al., TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals. Mol Endocrinol. 1995 Dec;9(12):1679-91
J:37130 Medvedev A, et al., Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element. Gene. 1996 Nov 28;181(1-2):199-206
J:44611 Medvedev A, et al., Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene. Genomics. 1997 Nov 15;46(1):93-102
J:51523 Villey I, et al., RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORgamma / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter. Eur J Immunol. 1999 Dec;29(12):4072-80
J:87395 Eberl G, et al., An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol. 2004 Jan;5(1):64-73
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:115922 Ivanov II, et al., The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006 Sep 22;126(6):1121-33
J:116733 Xie H, et al., RORgammat recruits steroid receptor coactivators to ensure thymocyte survival. J Immunol. 2005 Sep 15;175(6):3800-9
J:122764 Liu C, et al., Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature. 2007 May 24;447(7143):477-81
J:131020 Yang XO, et al., T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity. 2008 Jan;28(1):29-39
J:136164 Zhou L, et al., TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 2008 May 8;453(7192):236-40
J:179376 Lamia KA, et al., Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature. 2011 Dec 22;480(7378):552-6
J:196163 Malhotra N, et al., A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity. 2013 Apr 18;38(4):681-93
J:199687 Takeda Y, et al., RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo. Nucleic Acids Res. 2012 Sep 1;40(17):8519-35
J:205648 Meissburger B, et al., Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma. EMBO Mol Med. 2011 Nov;3(11):637-51
J:205671 Wang Y, et al., Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands. J Biol Chem. 2010 Feb 12;285(7):5013-25
J:207076 Kang HS, et al., Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism. Physiol Genomics. 2007 Oct 22;31(2):281-94
J:213087 Takeda Y, et al., Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors alpha- and gamma-mediated transactivation. Nucleic Acids Res. 2013 Aug;41(14):6992-7008
J:228005 Wang C, et al., CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity. Cell. 2015 Dec 3;163(6):1413-27
J:274080 Lee SM, et al., Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism. Hepatology. 2015 Feb;61(2):497-505