Sequence Detail

ID/Version

P52480 Q3TBV8 Q4VC20 Q3U5P6 Q91YI8 Q3TC59 Q3U1X3 Q3TBW5 Q9CWB1 Q64484 (UniProt | EBI)

Last sequence update: 2007-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Pyruvate kinase PKM; EC=2.7.1.40 {ECO:0000250|UniProtKB:P14618};AltName: Full=Pyruvate kinase muscle isozyme;AltName: Full=Threonine-protein kinase PKM2 {ECO:0000305}; EC=2.7.11.1 {ECO:0000250|UniProtKB:P14618};AltName: Full=

Provider

SWISS-PROT

Sequence

Polypeptide 531 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pkm	pyruvate kinase, muscle	64	124	4	149

Sequence references in MGI

J:26187 Izumi S, et al., Molecular cloning of the complementary DNA for the mouse pyruvate kinase M-2 gene whose expression is dependent upon cell differentiation. Biochim Biophys Acta. 1995 Jun 20;1267(2-3):135-8
J:46540 de Luis O, et al., Gene expression of mouse M1 and M2 pyruvate kinase isoenzymes correlates with differential poly[A] tract extension of their mRNAs during the development of spermatogenesis. Biochim Biophys Acta. 1998 Mar 13;1396(3):294-305
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100999 Giannakopoulos NV, et al., Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem Biophys Res Commun. 2005 Oct 21;336(2):496-506
J:131445 Lee J, et al., Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int J Biochem Cell Biol. 2008;40(5):1043-54
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:269368 Zhou HL, et al., Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Nature. 2019 Jan;565(7737):96-100
J:271270 Deng W, et al., The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis. Cell Rep. 2018 Jul 10;24(2):366-378
J:277769 Simsek D, et al., The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity. Cell. 2017 Jun 1;169(6):1051-1065.e18
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89