Sequence Detail

ID/Version

P53566 Q91XB6 (UniProt | EBI)

Last sequence update: 2002-01-23
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=CCAAT/enhancer-binding protein alpha {ECO:0000312|MGI:MGI:99480}; Short=C/EBP alpha {ECO:0000312|MGI:MGI:99480};

Provider

SWISS-PROT

Sequence

Polypeptide 359 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cebpa	CCAAT/enhancer binding protein alpha	136	153	3	27

Sequence references in MGI

J:19079 Christy RJ, et al., CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2593-7
J:35795 Flodby P, et al., Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J Biol Chem. 1996 Oct 4;271(40):24753-60
J:72330 Porse BT, et al., E2f repression by c/ebpalpha is required for adipogenesis and granulopoiesis in vivo. Cell. 2001 Oct 19;107(2):247-58
J:94195 Begay V, et al., Essential requirement of CCAAT/enhancer binding proteins in embryogenesis. Mol Cell Biol. 2004 Nov;24(22):9744-51
J:94682 Zhang P, et al., Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity. 2004 Dec;21(6):853-63
J:117723 Qiao L, et al., SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J Biol Chem. 2006 Dec 29;281(52):39915-24
J:120098 Pedersen TA, et al., Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo. EMBO J. 2007 Feb 21;26(4):1081-93
J:124079 Sekine K, et al., Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development. EMBO J. 2007 Aug 8;26(15):3607-15
J:152000 Kajimura S, et al., Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009 Aug 27;460(7259):1154-8
J:208356 Ohlsson E, et al., Initiation of MLL-rearranged AML is dependent on C/EBPalpha. J Exp Med. 2014 Jan 13;211(1):5-13
J:218372 Samuelsson L, et al., The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development. EMBO J. 1991 Dec;10(12):3787-93
J:219103 Wang GL, et al., Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev. 2004 Apr 15;18(8):912-25
J:219106 Muller C, et al., The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest. J Biol Chem. 2004 Feb 20;279(8):7353-8
J:237490 Brunmeir R, et al., Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PLoS Genet. 2016 Dec;12(12):e1006474
J:330954 Zhang Z, et al., Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis. Cell Metab. 2022 Nov 1;34(11):1860-1874.e4