Sequence Detail

ID/Version

P53690 O08645 O35369 Q8BTX2 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Matrix metalloproteinase-14; Short=MMP-14; EC=3.4.24.80 {ECO:0000305|PubMed:10737763};AltName: Full=MMP-X1;AltName: Full=MT-MMP;AltName: Full=Membrane-type matrix metalloproteinase 1; Short=MT-MMP 1; Short=MTM

Provider

SWISS-PROT

Sequence

Polypeptide 582 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mmp14	matrix metallopeptidase 14 (membrane-inserted)	79	120	4	28

Sequence references in MGI

J:32782 Okada A, et al., Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2730-4
J:43437 Apte SS, et al., The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis. J Biol Chem. 1997 Oct 10;272(41):25511-7
J:48622 Ota K, et al., Cloning of murine membrane-type-1-matrix metalloproteinase (MT-1-MMP) and its metanephric developmental regulation with respect to MMP-2 and its inhibitor. Kidney Int. 1998 Jul;54(1):131-42
J:57969 Holmbeck K, et al., MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell. 1999 Oct 1;99(1):81-92
J:61685 Zhou Z, et al., Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4052-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:110103 Rozanov DV, et al., Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice. Cancer Res. 2006 Jun 15;66(12):6258-63