Sequence Detail

ID/Version

P54310 P97866 Q8CDI9 Q3TE34 Q6GU16 (UniProt | EBI)

Last sequence update: 2006-01-24
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Hormone-sensitive lipase; Short=HSL; EC=3.1.1.79 {ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:20625037, ECO:0000269|PubMed:23066022};AltName: Full=Monoacylglycerol lipase LIPE; EC=3.1.1.23 {ECO:0000269|PubMed:2145

Provider

SWISS-PROT

Sequence

Polypeptide 759 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lipe	lipase, hormone sensitive	49	104	4	13

Sequence references in MGI

J:21904 Li Z, et al., Isolation and characterization of the gene for mouse hormone-sensitive lipase. Genomics. 1994 Nov 15;24(2):259-65
J:38915 Sztrolovics R, et al., Hormone-sensitive lipase (Lipe): sequence analysis of the 129Sv mouse Lipe gene. Mamm Genome. 1997 Feb;8(2):86-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:165450 Buchebner M, et al., Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363. J Lipid Res. 2010 Oct;51(10):2896-908
J:172679 Taschler U, et al., Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance. J Biol Chem. 2011 May 20;286(20):17467-77
J:175186 Daval M, et al., Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J Biol Chem. 2005 Jul 1;280(26):25250-7
J:192630 Eichmann TO, et al., Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J Biol Chem. 2012 Nov 30;287(49):41446-57
J:194928 Liew CW, et al., Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 2013 Feb;19(2):217-26
J:207819 Wang H, et al., Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. J Biol Chem. 2009 Nov 13;284(46):32116-25
J:289460 Zimmermann R, et al., Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science. 2004 Nov 19;306(5700):1383-6
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89