Sequence Detail

ID/Version

P54987 Q3TAA1 Q3U8E8 Q8CBA6 (UniProt | EBI)

Last sequence update: 2006-12-12
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cis-aconitate decarboxylase; Short=CAD; EC=4.1.1.6 {ECO:0000269|PubMed:23610393, ECO:0000269|PubMed:31548418};AltName: Full=Aconitate decarboxylase;AltName: Full=Aconitate decarboxylase 1 {ECO:0000312|MGI:MGI:103206};AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 488 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Acod1	aconitate decarboxylase 1	35	96	3	12

Sequence references in MGI

J:25077 Lee CG, et al., Cloning and analysis of gene regulation of a novel LPS-inducible cDNA. Immunogenetics. 1995;41(5):263-70
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:196639 Cheon YP, et al., Immune-responsive gene 1 is a novel target of progesterone receptor and plays a critical role during implantation in the mouse. Endocrinology. 2003 Dec;144(12):5623-30
J:196718 Degrandi D, et al., The proinflammatory cytokine-induced IRG1 protein associates with mitochondria. J Interferon Cytokine Res. 2009 Jan;29(1):55-67
J:196954 Michelucci A, et al., Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7820-5
J:196955 Li Y, et al., Immune Responsive Gene 1 (IRG1) Promotes Endotoxin Tolerance by Increasing A20 Expression in Macrophages through Reactive Oxygen Species. J Biol Chem. 2013 Jun 7;288(23):16225-34
J:279203 Daniels BP, et al., The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. Immunity. 2019 Jan 15;50(1):64-76.e4
J:325954 Chen F, et al., Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20644-20654
J:342735 Zhang Z, et al., Itaconate is a lysosomal inducer that promotes antibacterial innate immunity. Mol Cell. 2022 Aug 4;82(15):2844-2857.e10