Sequence Detail

ID/Version

P55014 Q9Z1E0 O35938 Q91W55 (UniProt | EBI)

Last sequence update: 2002-12-13
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Solute carrier family 12 member 1;AltName: Full=BSC1;AltName: Full=Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2;AltName: Full=Kidney-specific Na-K-Cl symporter;

Provider

SWISS-PROT

Sequence

Polypeptide 1095 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc12a1	solute carrier family 12, member 1	38	124	3	11

Sequence references in MGI

J:28941 Igarashi P, et al., Cloning, embryonic expression, and alternative splicing of a murine kidney-specific Na-K-Cl cotransporter. Am J Physiol. 1995 Sep;269(3 Pt 2):F405-18
J:53985 Mount DB, et al., Isoforms of the Na-K-2Cl cotransporter in murine TAL I. Molecular characterization and intrarenal localization. Am J Physiol. 1999 Mar;276(3 Pt 2):F347-58
J:75682 Plata C, et al., Functional properties of the apical Na+-K+-2Cl- cotransporter isoforms. J Biol Chem. 2002 Mar 29;277(13):11004-12
J:162573 Reiche J, et al., SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2. Mol Cell Biol. 2010 Jun;30(12):3027-37
J:177443 Lin SH, et al., Impaired phosphorylation of Na+-K+-2Cl- cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17538-43
J:182998 Richardson C, et al., Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci. 2011 Mar 1;124(Pt 5):789-800
J:284463 Frische S, et al., H(+)-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F429-F444
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89