Sequence Detail

ID/Version

P55258 Q8VCF6 (UniProt | EBI)

Last sequence update: 2005-11-22
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Ras-related protein Rab-8A; EC=3.6.5.2 {ECO:0000305|PubMed:16541104};AltName: Full=Oncogene c-mel;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 207 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rab8a	RAB8A, member RAS oncogene family	100	99	3	12

Sequence references in MGI

J:11402 Nimmo ER, et al., The MEL gene: a new member of the RAB/YPT class of RAS-related genes. Oncogene. 1991 Aug;6(8):1347-51
J:36261 Ren M, et al., In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. Proc Natl Acad Sci U S A. 1996 May 14;93(10):5151-5
J:83108 Fukuda M, Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. J Biol Chem. 2003 Apr 25;278(17):15373-80
J:83162 Fukuda M, Slp4-a/Granuphilin-a Inhibits Dense-core Vesicle Exocytosis through Interaction with the GDP-bound Form of Rab27A in PC12 Cells. J Biol Chem. 2003 Apr 25;278(17):15390-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:125105 Yang H, et al., Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. Genomics. 2007 Aug;90(2):249-60
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:152919 Hsiao YC, et al., Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking. Hum Mol Genet. 2009 Oct 15;18(20):3926-41
J:162627 Kinzel D, et al., Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev Cell. 2010 Jul 20;19(1):66-77
J:200405 Yamamura R, et al., The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions. Mol Biol Cell. 2008 Mar;19(3):971-83
J:222401 Zhang B, et al., GSK3beta-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis. PLoS Biol. 2015 Apr;13(4):e1002129
J:230329 Steger M, et al., Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. Elife. 2016;5:e12813
J:255588 Steger M, et al., Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. Elife. 2017 Nov 10;6:e31012
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89