Sequence Detail

ID/Version

P56198 Q8BNV7 Q499X5 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Lipid transferase CIDEC {ECO:0000305};AltName: Full=Cell death-inducing DFFA-like effector protein C {ECO:0000305};AltName: Full=Fat-specific protein FSP27 {ECO:0000303|PubMed:1339452};

Provider

SWISS-PROT

Sequence

Polypeptide 239 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cidec	cell death-inducing DFFA-like effector c	25	99	3	19

Sequence references in MGI

J:154 Danesch U, et al., Cloning and transcriptional regulation of a novel adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein (C/EBP) and C/EBP-like proteins interact with sequences required for differentiation-dependent expression. J Biol Chem. 1992 Apr 5;267(10):7185-93
J:85229 Zhou Z, et al., Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet. 2003 Sep;35(1):49-56
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:136384 Puri V, et al., Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7833-8
J:140122 Toh SY, et al., Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS One. 2008;3(8):e2890
J:140863 Nishino N, et al., FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest. 2008 Aug;118(8):2808-21
J:178919 Gong J, et al., Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell Biol. 2011 Dec 12;195(6):953-63
J:181181 Wang W, et al., Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nat Med. 2012;18(2):235-43
J:194299 Ueno M, et al., Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress. J Lipid Res. 2013 Mar;54(3):734-43
J:272806 Wang J, et al., Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids. J Biol Chem. 2018 Dec 14;293(50):19330-19343
J:317940 Xu W, et al., Differential Roles of Cell Death-inducing DNA Fragmentation Factor-alpha-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes. J Biol Chem. 2016 Feb 26;291(9):4282-93
J:333997 Qian K, et al., CLSTN3beta enforces adipocyte multilocularity to facilitate lipid utilization. Nature. 2023 Jan;613(7942):160-168
J:334000 Lyu X, et al., A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion. Dev Cell. 2021 Sep 27;56(18):2592-2606.e7
J:334175 Sun Z, et al., Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes. Nat Commun. 2013;4:1594