Sequence Detail

ID/Version

P56501 O88293 (UniProt | EBI)

Last sequence update: 1998-07-15
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Putative mitochondrial transporter UCP3 {ECO:0000305};AltName: Full=Solute carrier family 25 member 9;AltName: Full=Uncoupling protein 3 {ECO:0000303|PubMed:10748196}; Short=UCP 3;

Provider

SWISS-PROT

Sequence

Polypeptide 308 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	29	109	3	11

Sequence references in MGI

J:47611 Shimokawa T, et al., Transcriptional regulation of muscle-specific genes during myoblast differentiation. Biochem Biophys Res Commun. 1998 May 8;246(1):287-92
J:49056 Yoshitomi H, et al., Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map. Gene. 1998 Jul 17;215(1):77-84
J:62312 Gong DW, et al., Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem. 2000 May 26;275(21):16251-7
J:62313 Vidal-Puig AJ, et al., Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem. 2000 May 26;275(21):16258-66
J:73905 Cadenas S, et al., The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. J Biol Chem. 2002 Jan 25;277(4):2773-8
J:163883 Lombardi A, et al., UCP3 translocates lipid hydroperoxide and mediates lipid hydroperoxide-dependent mitochondrial uncoupling. J Biol Chem. 2010 May 28;285(22):16599-605
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:333168 Hirasaka K, et al., UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion. Biochem Biophys Res Commun. 2016 Mar 25;472(1):108-13
J:333169 Macher G, et al., Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate. Biochim Biophys Acta Biomembr. 2018 Mar;1860(3):664-672