Sequence Detail

ID/Version

P56818 Q544D0 (UniProt | EBI)

Last sequence update: 2001-08-14
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Beta-secretase 1 {ECO:0000305}; EC=3.4.23.46 {ECO:0000269|PubMed:29325091};AltName: Full=Aspartyl protease 2; Short=ASP2; Short=Asp 2;AltName: Full=Beta-site amyloid precursor protein cleaving enzyme 1; Short=

Provider

SWISS-PROT

Sequence

Polypeptide 501 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bace1	beta-site APP cleaving enzyme 1	92	101	3	26

Sequence references in MGI

J:43334 Vassar R, et al., Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE [see comments]. Science. 1999 Oct 22;286(5440):735-41
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100925 Dominguez D, et al., Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem. 2005 Sep 2;280(35):30797-806
J:104263 Spoelgen R, et al., Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J Neurosci. 2006 Jan 11;26(2):418-28
J:155532 Ohno M, et al., Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nat Neurosci. 2009 Dec;12(12):1506-13
J:182823 Jonas MC, et al., AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability. J Cell Sci. 2010 Oct 1;123(Pt 19):3378-88
J:229208 Kizuka Y, et al., An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med. 2015 Feb;7(2):175-89
J:232987 Vetrivel KS, et al., Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem. 2009 Feb 6;284(6):3793-803
J:237673 Kizuka Y, et al., Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. Biochem J. 2016 Jan 01;473(1):21-30
J:266459 Das U, et al., Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013 Aug 7;79(3):447-60
J:276403 Wang X, et al., alpha-secretase ADAM10 physically interacts with beta-secretase BACE1 in neurons and regulates CHL1 proteolysis. J Mol Cell Biol. 2018 Oct 1;10(5):411-422
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89