Sequence Detail

ID/Version

P56857 Q91ZZ0 Q91ZY9 Q91ZZ1 (UniProt | EBI)

Last sequence update: 2000-05-30
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Claudin-18;

Provider

SWISS-PROT

Sequence

Polypeptide 264 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cldn18	claudin 18	33	112	3	12

Sequence references in MGI

J:72106 Niimi T, et al., claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing. Mol Cell Biol. 2001 Nov;21(21):7380-90
J:153096 Hou J, et al., Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15350-5
J:195931 Kim HY, et al., Disruption of claudin-18 diminishes ovariectomy-induced bone loss in mice. Am J Physiol Endocrinol Metab. 2013 Mar 1;304(5):E531-7
J:196719 Linares GR, et al., Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation. J Bone Miner Res. 2012 Jul;27(7):1553-65
J:232069 LaFemina MJ, et al., Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice. Am J Respir Cell Mol Biol. 2014 Oct;51(4):550-8
J:232161 Li G, et al., Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug;51(2):210-22
J:260802 Zhou B, et al., Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018 Mar 1;128(3):970-984
J:292389 Hayashi D, et al., Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1beta, and atrophic gastritis in mice. Gastroenterology. 2012 Feb;142(2):292-304
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89