Sequence Detail

ID/Version

P60766 P21181 Q8BQ51 Q3TJK6 Q6P201 Q3THZ7 Q545V0 A2A9U6 P25763 (UniProt | EBI)

Last sequence update: 2011-02-08
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Cell division control protein 42 homolog {ECO:0000305}; EC=3.6.5.2 {ECO:0000269|PubMed:24352656, ECO:0000269|PubMed:26969129};AltName: Full=G25K GTP-binding protein;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 191 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdc42	cell division cycle 42	203	145	3	81

Sequence references in MGI

J:4309 Miki T, et al., Oncogene ect2 is related to regulators of small GTP-binding proteins [published erratum appears in Nature 1993 Aug 19;364(6439):737]. Nature. 1993 Apr 1;362(6419):462-5
J:36986 Marks PW, et al., Genomic organization and chromosomal location of murine Cdc42. Genomics. 1996 Nov 15;38(1):13-8
J:41876 Gong TW, et al., Complete cDNAs for CDC42 from chicken cochlea and mouse liver. Biochim Biophys Acta. 1997 Jun 26;1352(3):282-92
J:46957 Alberts AS, et al., Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. J Biol Chem. 1998 Apr 10;273(15):8616-22
J:65159 Joberty G, et al., The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol Cell Biol. 1999 Oct;19(10):6585-97
J:69174 Joberty G, et al., The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2000 Aug;2(8):531-9
J:83822 Chiang SH, et al., TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J. 2003 Jun 1;22(11):2679-91
J:96146 Nishikimi A, et al., Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. FEBS Lett. 2005 Feb 14;579(5):1039-46
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:118143 Kostenko EV, et al., Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. Mol Cell Biol. 2006 Dec;26(23):8964-75
J:185165 Harada Y, et al., DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood. 2012 May 10;119(19):4451-61
J:213034 Raynaud F, et al., Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis. J Biol Chem. 2014 Jan 31;289(5):2600-9
J:238439 Sarowar T, et al., Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2. Mol Brain. 2016 Mar 11;9:28
J:239194 Jaudon F, et al., The RhoGEF DOCK10 is essential for dendritic spine morphogenesis. Mol Biol Cell. 2015 Jun 01;26(11):2112-27
J:239198 Sakabe I, et al., Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells. Immun Ageing. 2012 Apr 11;9:2
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:323745 Brudvig JJ, et al., MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network. Sci Rep. 2018 Sep 5;8(1):13278