Sequence Detail

ID/Version

P61027 Q9D7X6 O88386 (UniProt | EBI)

Last sequence update: 2004-04-26
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Ras-related protein Rab-10; EC=3.6.5.2;

Provider

SWISS-PROT

Sequence

Polypeptide 200 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rab10	RAB10, member RAS oncogene family	77	99	3	29

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:189988 Sano H, et al., Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. Cell Metab. 2007 Apr;5(4):293-303
J:190284 Babbey CM, et al., Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells. Am J Physiol Renal Physiol. 2010 Sep;299(3):F495-506
J:190289 Chen Y, et al., GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation. Biochem J. 2009 Sep 1;422(2):229-35
J:191891 Chen Y, et al., Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. J Cell Biol. 2012 Aug 20;198(4):545-60
J:196254 Sano H, et al., Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. J Biol Chem. 2011 May 13;286(19):16541-5
J:230329 Steger M, et al., Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. Elife. 2016;5:e12813
J:236793 Bruno J, et al., SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. J Cell Biol. 2016 Jul 4;214(1):61-76
J:240261 Davey JR, et al., TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes. Traffic. 2012 Oct;13(10):1429-41
J:255588 Steger M, et al., Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. Elife. 2017 Nov 10;6:e31012
J:266343 Eguchi T, et al., LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9115-E9124
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:316366 Dhekne HS, et al., A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. Elife. 2018 Nov 6;7:e40202