Sequence Detail

ID/Version

P61202 O88950 Q9UNQ5 Q15647 Q8R5B0 Q9R249 Q9CWU1 Q3V1W6 (UniProt | EBI)

Last sequence update: 2004-05-10
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=COP9 signalosome complex subunit 2; Short=SGN2; Short=Signalosome subunit 2;AltName: Full=Alien homolog;AltName: Full=JAB1-containing signalosome subunit 2;AltName: Full=Thyroid receptor-interacting protein 15; Short=

Provider

SWISS-PROT

Sequence

Polypeptide 443 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cops2	COP9 signalosome subunit 2	28	109	3	18

Sequence references in MGI

J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
J:51125 Schaefer L, et al., Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien. Genomics. 1999 Mar 15;56(3):310-6
J:85761 Lykke-Andersen K, et al., Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol. 2003 Oct;23(19):6790-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:219109 Akiyama H, et al., The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2. J Biol Chem. 2003 Mar 21;278(12):10752-62
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89