Sequence Detail

ID/Version

P63005 Q9R2A6 P43035 P81692 O35592 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Platelet-activating factor acetylhydrolase IB subunit beta {ECO:0000255|HAMAP-Rule:MF_03141, ECO:0000305};AltName: Full=Lissencephaly-1 protein {ECO:0000255|HAMAP-Rule:MF_03141}; Short=LIS-1 {ECO:0000255|HAMAP-Rule:MF_03141};AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 410 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pafah1b1	platelet-activating factor acetylhydrolase, isoform 1b, subunit 1	154	136	4	336

Sequence references in MGI

J:22395 Peterfy M, et al., Lissencephaly-1 is one of the most conserved proteins between mouse and human: a single amino-acid difference in 410 residues. Gene. 1994 Dec 15;150(2):415-6
J:25562 Reiner O, et al., Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration. J Neurosci. 1995 May;15(5 Pt 2):3730-8
J:45961 Peterfy M, et al., Cloning and characterization of cDNAs and the gene encoding the mouse platelet-activating factor acetylhydrolase Ib alpha subunit/lissencephaly-1 protein. Genomics. 1998 Jan 15;47(2):200-6
J:66487 Niethammer M, et al., NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron. 2000 Dec;28(3):697-711
J:66488 Feng Y, et al., LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron. 2000 Dec;28(3):665-79
J:66505 Sasaki S, et al., A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron. 2000 Dec;28(3):681-96
J:68112 Sweeney KJ, et al., NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins. Mech Dev. 2001 Mar;101(1-2):21-33
J:69631 Cahana A, et al., Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6429-34
J:73763 Grattan M, et al., Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci. Diabetes. 2002 Jan;51(1):215-23
J:82792 Koizumi H, et al., Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis. J Biol Chem. 2003 Apr 4;278(14):12489-94
J:84075 Toyo-oka K, et al., 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet. 2003 Jul;34(3):274-85
J:85521 Cahana A, et al., A study of the nature of embryonic lethality in LIS1-/- mice. Mol Reprod Dev. 2003 Oct;66(2):134-42
J:85751 Kholmanskikh SS, et al., Disregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neurons. J Neurosci. 2003 Sep 24;23(25):8673-81
J:86398 Assadi AH, et al., Interaction of reelin signaling and Lis1 in brain development. Nat Genet. 2003 Nov;35(3):270-6
J:87104 Dujardin DL, et al., A role for cytoplasmic dynein and LIS1 in directed cell movement. J Cell Biol. 2003 Dec 22;163(6):1205-11
J:89815 Tokuoka SM, et al., Involvement of platelet-activating factor and LIS1 in neuronal migration. Eur J Neurosci. 2003 Aug;18(3):563-70
J:94756 Feng Y, et al., Mitotic spindle regulation by Nde1 controls cerebral cortical size. Neuron. 2004 Oct 14;44(2):279-93
J:99719 Soukoulis V, et al., Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8549-54
J:100552 Sasaki S, et al., Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol Cell Biol. 2005 Sep;25(17):7812-27
J:102751 Toyo-Oka K, et al., Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. Hum Mol Genet. 2005 Nov 1;14(21):3113-28
J:105269 Kholmanskikh SS, et al., Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility. Nat Neurosci. 2006 Jan;9(1):50-7
J:111760 Guo J, et al., Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. Mol Biol Cell. 2006 Feb;17(2):680-9
J:119418 Yamaguchi N, et al., Expression of NUDEL in manchette and its implication in spermatogenesis. FEBS Lett. 2004 May 21;566(1-3):71-6
J:128546 Coquelle FM, et al., LIS1, CLIP-170's key to the dynein/dynactin pathway. Mol Cell Biol. 2002 May;22(9):3089-102
J:129338 Zhang G, et al., The Pafah1b complex interacts with the Reelin receptor VLDLR. PLoS One. 2007;2(2):e252
J:200248 Jodoin JN, et al., Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. Mol Biol Cell. 2012 Dec;23(24):4713-24
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296157 Tarricone C, et al., Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. Neuron. 2004 Dec 2;44(5):809-21