Sequence Detail

ID/Version

P63073 P20415 (UniProt | EBI)

Last sequence update: 2004-09-13
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Eukaryotic translation initiation factor 4E {ECO:0000303|PubMed:2663851}; Short=eIF-4E {ECO:0000303|PubMed:2663851}; Short=eIF4E {ECO:0000303|PubMed:2663851}; Short=mRNA cap-binding protein;AltName: Full=eIF-4F 25 kDa

Provider

SWISS-PROT

Sequence

Polypeptide 217 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Eif4e	eukaryotic translation initiation factor 4E	95	116	4	69

Sequence references in MGI

J:9886 Altmann M, et al., A mammalian translation initiation factor can substitute for its yeast homologue in vivo. J Biol Chem. 1989 Jul 25;264(21):12145-7
J:11203 Jaramillo M, et al., Multiple mRNAs encode the murine translation initiation factor eIF-4E. J Biol Chem. 1991 Jun 5;266(16):10446-51
J:41062 Marcotrigiano J, et al., Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell. 1997 Jun 13;89(6):951-61
J:92370 Nedelec S, et al., Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10815-20
J:109618 Jung MY, et al., Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein. Mol Cell Biol. 2006 Jun;26(11):4277-87
J:118799 Cohen N, et al., PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA. EMBO J. 2001 Aug 15;20(16):4547-59
J:147897 Unhavaithaya Y, et al., MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem. 2009 Mar 6;284(10):6507-19
J:156046 Napoli I, et al., The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell. 2008 Sep 19;134(6):1042-54
J:189932 Peruquetti RL, et al., Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. PLoS One. 2012;7(8):e42695
J:217461 Yang G, et al., An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Neuron. 2014 Nov 19;84(4):723-39
J:245369 Yu C, et al., BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes. Nat Struct Mol Biol. 2016 May;23(5):387-94
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:335658 Rousseau D, et al., Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1065-70
J:335664 Topisirovic I, et al., Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities. Cancer Res. 2004 Dec 1;64(23):8639-42