Sequence Detail

ID/Version

P63085 Q3V1U6 P27703 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Mitogen-activated protein kinase 1 {ECO:0000305}; Short=MAP kinase 1; Short=MAPK 1; EC=2.7.11.24;AltName: Full=ERT1;AltName: Full=Extracellular signal-regulated kinase 2; Short=ERK-2;AltName: Full=MAP kinase i

Provider

SWISS-PROT

Sequence

Polypeptide 358 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mapk1	mitogen-activated protein kinase 1	170	258	3	33

Sequence references in MGI

J:4073 Ershler M, et al., Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. Gene. 1993 Feb 28;124(2):305-6
J:17364 Her JH, et al., Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by tyrosine phosphorylation. Nucleic Acids Res. 1991 Jul 11;19(13):3743
J:31652 Sun H, et al., MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell. 1993 Nov 5;75(3):487-93
J:78465 Murphy LO, et al., Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol. 2002 Aug;4(8):556-64
J:89950 Vomastek T, et al., Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. Proc Natl Acad Sci U S A. 2004 May 4;101(18):6981-6
J:98544 Hsu SH, et al., bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis. Cancer Res. 2005 May 15;65(10):4041-50
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102896 Parra JL, et al., Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties. J Biol Chem. 2005 Nov 11;280(45):37623-33
J:178099 Maragno AL, et al., ISG15 modulates development of the erythroid lineage. PLoS One. 2011;6(10):e26068
J:180564 Yao Z, et al., The ERK signaling cascade--views from different subcellular compartments. Biofactors. 2009 Sep-Oct;35(5):407-16
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:332980 Del'Guidice T, et al., FXR1P is a GSK3beta substrate regulating mood and emotion processing. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4610-9
J:334025 Tischer T, et al., The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse Oocytes. Cell Rep. 2016 Oct 25;17(5):1426-1437