ID/Version |
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Sequence description from provider |
RecName: Full=Pleiotrophin {ECO:0000250|UniProtKB:P21246}; Short=PTN {ECO:0000250|UniProtKB:P21246};AltName: Full=Heparin-binding brain mitogen {ECO:0000250|UniProtKB:P21246}; Short=HBBM {ECO:0000250|UniProtKB:P21246};AltName: Full=Heparin | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
168
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:2332
Naito A, et al., Similarity of the genomic structure between the two members in a new family of heparin-binding factors. Biochem Biophys Res Commun. 1992 Mar 16;183(2):701-7
J:3471 Katoh K, et al., Genomic organization of the mouse OSF-1 gene. DNA Cell Biol. 1992 Dec;11(10):735-43 J:10881 Tezuka K, et al., Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues. Biochem Biophys Res Commun. 1990 Nov 30;173(1):246-51 J:70253 Amet LE, et al., Enhanced hippocampal long-term potentiation in mice lacking heparin-binding growth-associated molecule. Mol Cell Neurosci. 2001 Jun;17(6):1014-24 J:77465 Pavlov I, et al., Role of Heparin-Binding Growth-Associated Molecule (HB-GAM) in Hippocampal LTP and Spatial Learning Revealed by Studies on Overexpressing and Knockout Mice. Mol Cell Neurosci. 2002 Jun;20(2):330-42 J:91002 Hienola A, et al., HB-GAM inhibits proliferation and enhances differentiation of neural stem cells. Mol Cell Neurosci. 2004 May;26(1):75-88 J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:110520 Zou P, et al., Mice doubly deficient in the midkine and pleiotrophin genes exhibit deficits in the expression of beta-tectorin gene and in auditory response. Lab Invest. 2006 Jul;86(7):645-53 J:123392 Muramatsu H, et al., Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors. Genes Cells. 2006 Dec;11(12):1405-17 J:177072 Istvanffy R, et al., Stromal pleiotrophin regulates repopulation behavior of hematopoietic stem cells. Blood. 2011 Sep 8;118(10):2712-22 J:218928 Krellman JW, et al., Behavioral and neuroanatomical abnormalities in pleiotrophin knockout mice. PLoS One. 2014;9(7):e100597 J:236151 Kuboyama K, et al., Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION. J Biol Chem. 2016 Aug 26;291(35):18117-28 J:273520 Imai S, et al., Osteocyte-derived HB-GAM (pleiotrophin) is associated with bone formation and mechanical loading. Bone. 2009 May;44(5):785-94 J:273547 Yu HF, et al., Ptn functions downstream of C/EBPbeta to mediate the effects of cAMP on uterine stromal cell differentiation through targeting Hand2 in response to progesterone. J Cell Physiol. 2018 Feb;233(2):1612-1626 J:281259 Tang C, et al., Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. Neuron. 2018 Nov 14; J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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