Sequence Detail

ID/Version

P63089 P20935 (UniProt | EBI)

Last sequence update: 2004-09-13
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Pleiotrophin {ECO:0000250|UniProtKB:P21246}; Short=PTN {ECO:0000250|UniProtKB:P21246};AltName: Full=Heparin-binding brain mitogen {ECO:0000250|UniProtKB:P21246}; Short=HBBM {ECO:0000250|UniProtKB:P21246};AltName: Full=Heparin

Provider

SWISS-PROT

Sequence

Polypeptide 168 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ptn	pleiotrophin	101	132	3	8

Sequence references in MGI

J:2332 Naito A, et al., Similarity of the genomic structure between the two members in a new family of heparin-binding factors. Biochem Biophys Res Commun. 1992 Mar 16;183(2):701-7
J:3471 Katoh K, et al., Genomic organization of the mouse OSF-1 gene. DNA Cell Biol. 1992 Dec;11(10):735-43
J:10881 Tezuka K, et al., Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues. Biochem Biophys Res Commun. 1990 Nov 30;173(1):246-51
J:70253 Amet LE, et al., Enhanced hippocampal long-term potentiation in mice lacking heparin-binding growth-associated molecule. Mol Cell Neurosci. 2001 Jun;17(6):1014-24
J:77465 Pavlov I, et al., Role of Heparin-Binding Growth-Associated Molecule (HB-GAM) in Hippocampal LTP and Spatial Learning Revealed by Studies on Overexpressing and Knockout Mice. Mol Cell Neurosci. 2002 Jun;20(2):330-42
J:91002 Hienola A, et al., HB-GAM inhibits proliferation and enhances differentiation of neural stem cells. Mol Cell Neurosci. 2004 May;26(1):75-88
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:110520 Zou P, et al., Mice doubly deficient in the midkine and pleiotrophin genes exhibit deficits in the expression of beta-tectorin gene and in auditory response. Lab Invest. 2006 Jul;86(7):645-53
J:123392 Muramatsu H, et al., Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors. Genes Cells. 2006 Dec;11(12):1405-17
J:177072 Istvanffy R, et al., Stromal pleiotrophin regulates repopulation behavior of hematopoietic stem cells. Blood. 2011 Sep 8;118(10):2712-22
J:218928 Krellman JW, et al., Behavioral and neuroanatomical abnormalities in pleiotrophin knockout mice. PLoS One. 2014;9(7):e100597
J:236151 Kuboyama K, et al., Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION. J Biol Chem. 2016 Aug 26;291(35):18117-28
J:273520 Imai S, et al., Osteocyte-derived HB-GAM (pleiotrophin) is associated with bone formation and mechanical loading. Bone. 2009 May;44(5):785-94
J:273547 Yu HF, et al., Ptn functions downstream of C/EBPbeta to mediate the effects of cAMP on uterine stromal cell differentiation through targeting Hand2 in response to progesterone. J Cell Physiol. 2018 Feb;233(2):1612-1626
J:281259 Tang C, et al., Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. Neuron. 2018 Nov 14;
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89