Sequence Detail

ID/Version

P67778 P24142 Q3UB75 Q5SQG4 (UniProt | EBI)

Last sequence update: 2004-10-11
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Prohibitin 1 {ECO:0000305};AltName: Full=B-cell receptor-associated protein 32; Short=BAP 32;

Provider

SWISS-PROT

Sequence

Polypeptide 272 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Phb1	prohibitin 1	116	99	3	22

Sequence references in MGI

J:19987 Terashima M, et al., The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. EMBO J. 1994 Aug 15;13(16):3782-92
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114058 Coates PJ, et al., Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. Exp Cell Res. 2001 May 1;265(2):262-73
J:191189 Lucas CR, et al., Prohibitins and the Cytoplasmic Domain of CD86 Cooperate To Mediate CD86 Signaling in B Lymphocytes. J Immunol. 2013 Jan 15;190(2):723-36
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:215238 Richter-Dennerlein R, et al., DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling. Cell Metab. 2014 Jul 1;20(1):158-71
J:230172 Ande SR, et al., Prohibitin overexpression in adipocytes induces mitochondrial biogenesis, leads to obesity development, and affects glucose homeostasis in a sex-specific manner. Diabetes. 2014 Nov;63(11):3734-41
J:273588 Strub GM, et al., Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J. 2011 Feb;25(2):600-12
J:289457 Too IHK, et al., Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis. PLoS Pathog. 2018 Jan;14(1):e1006778
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89