Sequence Detail

ID/Version

P70181 O70335 Q8JZY6 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase type-1 beta {ECO:0000305|PubMed:18772378}; Short=PIP5KI-beta {ECO:0000305|PubMed:18772378}; Short=PtdIns(4)P-5-kinase 1 beta {ECO:0000305|PubMed:18772378}; EC=2.7.1.68 {ECO:00

Provider

SWISS-PROT

Sequence

Polypeptide 539 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pip5k1b	phosphatidylinositol-4-phosphate 5-kinase, type 1 beta	15	102	4	23

Sequence references in MGI

J:35632 Ishihara H, et al., Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1996 Sep 27;271(39):23611-4
J:46962 Ishihara H, et al., Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/ substitution analysis of members of this novel lipid kinase family. J Biol Chem. 1998 Apr 10;273(15):8741-8
J:99138 Kisseleva M, et al., The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. Mol Cell Biol. 2005 May;25(10):3956-66
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:139076 Wang Y, et al., Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14064-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297318 Shulga YV, et al., Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator. J Biol Chem. 2012 Oct 19;287(43):35953-63
J:297456 Rameh LE, et al., A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. Nature. 1997 Nov 13;390(6656):192-6