Sequence Detail

ID/Version

P70232 Q8C6W0 Q8VBY7 Q8BS24 A2RRK1 Q8C823 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Neural cell adhesion molecule L1-like protein;AltName: Full=Cell adhesion molecule with homology to L1CAM;AltName: Full=Chl1-like protein;AltName: Full=Close homolog of L1;Contains: RecName: Full=Processed neural cell adhesion molecule L1-l

Provider

SWISS-PROT

Sequence

Polypeptide 1209 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Chl1	cell adhesion molecule L1-like	15	110	4	5

Sequence references in MGI

J:36169 Holm J, et al., Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules. Eur J Neurosci. 1996 Aug;8(8):1613-29
J:55994 Hillenbrand R, et al., The close homologue of the neural adhesion molecule L1 (CHL1): patterns of expression and promotion of neurite outgrowth by heterophilic interactions. Eur J Neurosci. 1999 Mar;11(3):813-26
J:79902 Montag-Sallaz M, et al., Misguided axonal projections, neural cell adhesion molecule 180 mRNA upregulation, and altered behavior in mice deficient for the close homolog of L1. Mol Cell Biol. 2002 Nov;22(22):7967-81
J:84464 Frints SG, et al., CALL interrupted in a patient with non-specific mental retardation: gene dosage-dependent alteration of murine brain development and behavior. Hum Mol Genet. 2003 Jul 1;12(13):1463-74
J:89492 Naus S, et al., Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J Biol Chem. 2004 Apr 16;279(16):16083-90
J:96214 Pratte M, et al., Mice deficient for the close homologue of the neural adhesion cell L1 (CHL1) display alterations in emotional reactivity and motor coordination. Behav Brain Res. 2003 Dec 17;147(1-2):31-9
J:96525 Demyanenko GP, et al., Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex. Neuron. 2004 Oct 28;44(3):423-37
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:108067 Nikonenko AG, et al., Enhanced perisomatic inhibition and impaired long-term potentiation in the CA1 region of juvenile CHL1-deficient mice. Eur J Neurosci. 2006 Apr;23(7):1839-52
J:166027 Buhusi M, et al., Close homolog of L1 is an enhancer of integrin-mediated cell migration. J Biol Chem. 2003 Jul 4;278(27):25024-31
J:276403 Wang X, et al., alpha-secretase ADAM10 physically interacts with beta-secretase BACE1 in neurons and regulates CHL1 proteolysis. J Mol Cell Biol. 2018 Oct 1;10(5):411-422
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89