Sequence Detail

ID/Version

P70338 O09063 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Zinc finger protein Gfi-1;AltName: Full=Growth factor independent protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 423 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gfi1	growth factor independent 1 transcription repressor	44	119	4	31

Sequence references in MGI

J:32921 Zornig M, et al., Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2. Oncogene. 1996 Apr 18;12(8):1789-801
J:37751 Scheijen B, et al., Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice. J Virol. 1997 Jan;71(1):9-16
J:80025 Wallis D, et al., The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development. 2003 Jan;130(1):221-32
J:112647 Heyd F, et al., Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing. Nat Immunol. 2006 Aug;7(8):859-67
J:144931 Grimes HL, et al., The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal. Mol Cell Biol. 1996 Nov;16(11):6263-72
J:162780 Sharif-Askari E, et al., Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65. Mol Cell Biol. 2010 Aug;30(16):3929-42
J:175166 Saleque S, et al., Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell. 2007 Aug 17;27(4):562-72
J:175175 Dahl R, et al., The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction. J Biol Chem. 2007 Mar 2;282(9):6473-83
J:265737 Vadnais C, et al., GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1. Nat Commun. 2018 Apr 12;9(1):1418