Sequence Detail

ID/Version

P70351 Q8BR85 Q3TPR1 Q922L1 Q3U3V5 Q9R089 Q3UU02 A2A4K5 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Histone-lysine N-methyltransferase EZH1; EC=2.1.1.356 {ECO:0000269|PubMed:19026780};AltName: Full=ENX-2;AltName: Full=Enhancer of zeste homolog 1;

Provider

SWISS-PROT

Sequence

Polypeptide 747 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ezh1	enhancer of zeste 1 polycomb repressive complex 2 subunit	35	115	3	12

Sequence references in MGI

J:41121 Laible G, et al., Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J. 1997 Jun 2;16(11):3219-32
J:45792 Ogawa M, et al., Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2. Biochim Biophys Acta. 1998 Jan 21;1395(2):151-8
J:50304 Laible G, et al., The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6. Mamm Genome. 1999 Mar;10(3):311-4
J:70827 Ehringer MA, et al., High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:142193 Shen X, et al., EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 2008 Nov 21;32(4):491-502
J:157068 Walker E, et al., Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2010 Feb 5;6(2):153-66
J:281161 Ragazzini R, et al., EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells. Nat Commun. 2019 Aug 26;10(1):3858