Sequence Detail

ID/Version

P70388 Q9CU59 Q8C2T7 Q6PEB0 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=DNA repair protein RAD50; Short=mRad50; EC=3.6.-.- {ECO:0000250|UniProtKB:Q92878};

Provider

SWISS-PROT

Sequence

Polypeptide 1312 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rad50	RAD50 double strand break repair protein	79	108	3	19

Sequence references in MGI

J:36725 Kim KK, et al., Mouse RAD50 has limited epitopic homology to p53 and is expressed in the adult myocardium. J Biol Chem. 1996 Nov 15;271(46):29255-64
J:56083 Luo G, et al., Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7376-81
J:78820 Bender CF, et al., Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev. 2002 Sep 1;16(17):2237-51
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:265834 Hung PJ, et al., MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell. 2018 Jul 19;71(2):332-342.e8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89