Sequence Detail

ID/Version

P70434 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Interferon regulatory factor 7; Short=IRF-7;

Provider

SWISS-PROT

Sequence

Polypeptide 457 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Irf7	interferon regulatory factor 7	56	107	3	9

Sequence references in MGI

J:97662 Honda K, et al., IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature. 2005 Apr 7;434(7034):772-7
J:153410 Daffis S, et al., Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection. J Virol. 2008 Sep;82(17):8465-75
J:180378 Hu Y, et al., Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7. J Immunol. 2011 Dec 15;187(12):6456-62
J:184127 Honda K, et al., Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity. 2006 Sep;25(3):349-60
J:205872 Wang J, et al., Negative regulation of Nmi on virus-triggered type I IFN production by targeting IRF7. J Immunol. 2013 Sep 15;191(6):3393-9
J:235021 Ren Y, et al., The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene. J Biol Chem. 2016 Jun 17;291(25):13206-15
J:336429 Kawai T, et al., Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol. 2004 Oct;5(10):1061-8