Sequence Detail

ID/Version

P70669 P97439 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Phosphate-regulating neutral endopeptidase PHEX {ECO:0000305};AltName: Full=Metalloendopeptidase homolog PEX; EC=3.4.24.- {ECO:0000250|UniProtKB:P78562};AltName: Full=Phosphate regulating neutral endopeptidase;AltName: Full=Vitamin D

Provider

SWISS-PROT

Sequence

Polypeptide 749 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Phex	phosphate regulating endopeptidase homolog, X-linked	28	103	3	18

Sequence references in MGI

J:34935 Du L, et al., cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone. Genomics. 1996 Aug 15;36(1):22-8
J:38621 Strom TM, et al., Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. Hum Mol Genet. 1997 Feb;6(2):165-71
J:39093 Beck L, et al., Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice. J Clin Invest. 1997 Mar 15;99(6):1200-9
J:67356 Miao D, et al., Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition. Endocrinology. 2001 Feb;142(2):926-39
J:112483 Thompson DL, et al., Ontogeny of Phex/PHEX protein expression in mouse embryo and subcellular localization in osteoblasts. J Bone Miner Res. 2002 Feb;17(2):311-20
J:153409 Addison WN, et al., MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM. J Bone Miner Res. 2008 Oct;23(10):1638-49
J:228153 Zelenchuk LV, et al., Age dependent regulation of bone-mass and renal function by the MEPE ASARM-motif. Bone. 2015 Oct;79:131-42
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89