Sequence Detail

ID/Version

P81067 Q5U3K8 Q3UPZ3 (UniProt | EBI)

Last sequence update: 2009-11-03
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Iroquois-class homeodomain protein IRX-3;AltName: Full=Homeodomain protein IRXB1;AltName: Full=Iroquois homeobox protein 3;

Provider

SWISS-PROT

Sequence

Polypeptide 507 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Irx3	Iroquois related homeobox 3	25	165	4	11

Sequence references in MGI

J:45549 Bellefroid EJ, et al., Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification. EMBO J. 1998 Jan 2;17(1):191-203
J:45683 Bosse A, et al., Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 1997 Dec;69(1-2):169-81
J:61328 Cohen DR, et al., Expression of two novel mouse iroquois homeobox genes during neurogenesis. Mech Dev. 2000 Mar 1;91(1-2):317-21
J:64020 Christoffels VM, et al., Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart. Dev Biol. 2000 Aug 15;224(2):263-74
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:125316 Reggiani L, et al., The prepattern transcription factor Irx3 directs nephron segment identity. Genes Dev. 2007 Sep 15;21(18):2358-70
J:128691 Lee SK, et al., Analysis of embryonic motoneuron gene regulation: derepression of general activators function in concert with enhancer factors. Development. 2004 Jul;131(14):3295-306
J:133641 Briscoe J, et al., A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell. 2000 May 12;101(4):435-45
J:208887 Smemo S, et al., Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014 Mar 20;507(7492):371-5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89