Sequence Detail

ID/Version

P97414 Q3U4H1 O88702 Q7TPL7 Q7TNZ1 Q80VR7 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Potassium voltage-gated channel subfamily KQT member 1;AltName: Full=IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 {ECO:0000305|PubMed:11120752};AltName: Full=KQT-like 1 {ECO:0000250|UniProtKB:P51787};AltName: Full=

Provider

SWISS-PROT

Sequence

Polypeptide 668 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	169	140	3	24

Sequence references in MGI

J:36442 Barhanin J, et al., K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current [see comments]. Nature. 1996 Nov 7;384(6604):78-80
J:48435 Paulsen M, et al., Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5. Hum Mol Genet. 1998 Jul;7(7):1149-59
J:66428 Lee MP, et al., Targeted disruption of the kvlqt1 gene causes deafness and gastric hyperplasia in mice. J Clin Invest. 2000 Dec;106(12):1447-55
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100283 Knollmann BC, et al., Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current. J Pharmacol Exp Ther. 2004 Jul;310(1):311-8
J:104389 Vallon V, et al., KCNQ1-dependent transport in renal and gastrointestinal epithelia. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17864-9
J:123033 Knollmann BC, et al., Kcnq1 contributes to an adrenergic-sensitive steady-state K(+) current in mouse heart. Biochem Biophys Res Commun. 2007 Aug 17;360(1):212-8
J:176794 Song P, et al., KCNQ1 is the luminal K+ recycling channel during stimulation of gastric acid secretion. J Physiol. 2009 Aug 1;587(Pt 15):3955-65
J:258659 Abbott GW, et al., KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. Sci Signal. 2014 Mar 4;7(315):ra22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89