Sequence Detail

ID/Version

P97460 (UniProt | EBI)

Last sequence update: 1997-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Neuronal PAS domain-containing protein 2; Short=Neuronal PAS2;

Provider

SWISS-PROT

Sequence

Polypeptide 816 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Npas2	neuronal PAS domain protein 2	38	108	3	7

Sequence references in MGI

J:37770 Zhou YD, et al., Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):713-8
J:84471 Dudley CA, et al., Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science. 2003 Jul 18;301(5631):379-83
J:109589 Franken P, et al., NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7118-23
J:121658 DeBruyne JP, et al., CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci. 2007 May;10(5):543-5
J:135199 Hampp G, et al., Regulation of monoamine oxidase a by circadian-clock components implies clock influence on mood. Curr Biol. 2008 May 6;18(9):678-83
J:135812 Bertolucci C, et al., Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators. Mol Cell Biol. 2008 May;28(9):3070-5
J:202325 Hwang CK, et al., Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells. J Neurosci. 2013 Sep 18;33(38):14989-97
J:205293 O'Neil D, et al., Dysregulation of Npas2 leads to altered metabolic pathways in a murine knockout model. Mol Genet Metab. 2013 Nov;110(3):378-87
J:207820 Curtis AM, et al., Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J Biol Chem. 2004 Feb 20;279(8):7091-7
J:209471 Yoshii K, et al., Effects of NAD(P)H and its derivatives on the DNA-binding activity of NPAS2, a mammalian circadian transcription factor. Biochem Biophys Res Commun. 2013 Aug 2;437(3):386-91
J:243859 Wu X, et al., NPAS2 deletion impairs responses to restricted feeding but not to metabolic challenges. Physiol Behav. 2010 Mar 30;99(4):466-71
J:271703 Ozburn AR, et al., NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors. Front Mol Neurosci. 2017;10:360
J:274080 Lee SM, et al., Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism. Hepatology. 2015 Feb;61(2):497-505