Sequence Detail

ID/Version

P97481 O55046 O08787 (UniProt | EBI)

Last sequence update: 1998-12-15
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Endothelial PAS domain-containing protein 1; Short=EPAS-1;AltName: Full=HIF-1-alpha-like factor; Short=HLF; Short=mHLF;AltName: Full=HIF-related factor; Short=HRF;AltName: Full=Hypoxia-inducible factor 2-alpha

Provider

SWISS-PROT

Sequence

Polypeptide 874 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Epas1	endothelial PAS domain protein 1	73	142	4	42

Sequence references in MGI

J:37851 Tian H, et al., Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 1997 Jan 1;11(1):72-82
J:40599 Flamme I, et al., HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels. Mech Dev. 1997 Apr;63(1):51-60
J:41526 Ema M, et al., A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4273-8
J:203396 Torii S, et al., Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. Cell Death Differ. 2011 Nov;18(11):1711-25
J:247431 Wu D, et al., Structural integration in hypoxia-inducible factors. Nature. 2015 Aug 20;524(7565):303-8