Sequence Detail

ID/Version

P97490 G3X8V9 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Adenylate cyclase type 8 {ECO:0000305}; EC=4.6.1.1 {ECO:0000250|UniProtKB:P40146};AltName: Full=ATP pyrophosphate-lyase 8;AltName: Full=Adenylate cyclase type VIII {ECO:0000250|UniProtKB:P40145};AltName: Full=Adenylyl cyclase 8 {ECO:

Provider

SWISS-PROT

Sequence

Polypeptide 1249 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adcy8	adenylate cyclase 8	105	103	3	12

Sequence references in MGI

J:57343 Wong ST, et al., Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron. 1999 Aug;23(4):787-98
J:63173 Schaefer ML, et al., Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice. J Neurosci. 2000 Jul 1;20(13):4809-20
J:86425 Wang H, et al., Type 8 adenylyl cyclase is targeted to excitatory synapses and required for mossy fiber long-term potentiation. J Neurosci. 2003 Oct 29;23(30):9710-8
J:107678 Wei F, et al., Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases. Neuron. 2002 Nov 14;36(4):713-26
J:122007 Conti AC, et al., Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain. Neuroscience. 2007 May 11;146(2):713-29
J:134966 Zhang M, et al., Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory. J Neurosci. 2008 Apr 30;28(18):4736-44
J:139609 Zachariou V, et al., Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies. Biol Psychiatry. 2008 Jun 1;63(11):1013-21
J:165305 Razzoli M, et al., Functional role of Calcium-stimulated adenylyl cyclase 8 in adaptations to psychological stressors in the mouse: implications for mood disorders. Neuroscience. 2010 Oct 13;170(2):429-40
J:220774 Raoux M, et al., Multilevel control of glucose homeostasis by adenylyl cyclase 8. Diabetologia. 2015 Apr;58(4):749-57
J:266106 Bernabucci M, et al., Calcium activated adenylyl cyclase AC8 but not AC1 is required for prolonged behavioral anxiety. Mol Brain. 2016 May 27;9(1):60
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87