Sequence Detail

ID/Version

P97784 (UniProt | EBI)

Last sequence update: 1997-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Cryptochrome-1;

Provider

SWISS-PROT

Sequence

Polypeptide 606 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cry1	cryptochrome circadian regulator 1	105	107	4	14

Sequence references in MGI

J:47904 Miyamoto Y, et al., Vitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals. Proc Natl Acad Sci U S A. 1998 May 26;95(11):6097-102
J:51295 Kobayashi K, et al., Characterization of photolyase/blue-light receptor homologs in mouse and human cells. Nucleic Acids Res. 1998 Nov 15;26(22):5086-92
J:57719 Miyamoto Y, et al., Circadian regulation of cryptochrome genes in the mouse. Brain Res Mol Brain Res. 1999 Aug 25;71(2):238-43
J:73655 Lee C, et al., Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 2001 Dec 28;107(7):855-67
J:87576 Lee C, et al., Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan;24(2):584-94
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:106987 Chaves I, et al., Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance. Mol Cell Biol. 2006 Mar;26(5):1743-53
J:116444 Etchegaray JP, et al., The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28;281(30):21209-15
J:122872 Siepka SM, et al., Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell. 2007 Jun 1;129(5):1011-23
J:147991 Ramsey KM, et al., Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science. 2009 May 1;324(5927):651-4
J:153754 Lamia KA, et al., AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science. 2009 Oct 16;326(5951):437-40
J:154857 Chen R, et al., Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell. 2009 Nov 13;36(3):417-30
J:156994 Schmutz I, et al., The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev. 2010 Feb 15;24(4):345-57
J:162577 Guillaumond F, et al., Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver. Mol Cell Biol. 2010 Jun;30(12):3059-70
J:170767 Ukai-Tadenuma M, et al., Delay in feedback repression by cryptochrome 1 is required for circadian clock function. Cell. 2011 Jan 21;144(2):268-81
J:173042 Hara Y, et al., Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter. Nucleic Acids Res. 2009 Mar;37(4):1115-26
J:176743 Koyanagi S, et al., cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J Biol Chem. 2011 Sep 16;286(37):32416-23
J:179376 Lamia KA, et al., Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature. 2011 Dec 22;480(7378):552-6
J:192252 Na J, et al., Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene. PLoS One. 2012;7(10):e48152
J:194037 Yoo SH, et al., Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm. Cell. 2013 Feb 28;152(5):1091-105
J:196293 Hirano A, et al., FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. Cell. 2013 Feb 28;152(5):1106-18
J:196953 Anand SN, et al., Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation. J Neurosci. 2013 Apr 24;33(17):7145-53
J:198214 Barclay JL, et al., High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice. Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1053-63
J:204645 Zhao WN, et al., CIPC is a mammalian circadian clock protein without invertebrate homologues. Nat Cell Biol. 2007 Mar;9(3):268-75
J:205586 Annayev Y, et al., Gene model 129 (gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J Biol Chem. 2014 Feb 21;289(8):5013-24
J:207239 Gao P, et al., Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length. J Biol Chem. 2013 Dec 6;288(49):35277-86
J:209425 Kang TH, et al., Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1. Nucleic Acids Res. 2014 Apr;42(7):4427-34
J:209461 Han DH, et al., Modulation of glucocorticoid receptor induction properties by core circadian clock proteins. Mol Cell Endocrinol. 2014 Mar 5;383(1-2):170-80
J:209472 Ono D, et al., Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus. Nat Commun. 2013;4:1666
J:209477 Ye R, et al., Biochemical analysis of the canonical model for the mammalian circadian clock. J Biol Chem. 2011 Jul 22;286(29):25891-902
J:209480 Zhang EE, et al., Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010 Oct;16(10):1152-6
J:209491 Naruse Y, et al., Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. Mol Cell Biol. 2004 Jul;24(14):6278-87
J:210938 Yagita K, et al., Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein. EMBO J. 2002 Mar 15;21(6):1301-14
J:212062 Engelen E, et al., Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock. PLoS One. 2013;8(2):e56623
J:213082 Li DQ, et al., Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun. 2013;4:2545
J:240095 Shi G, et al., Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Cell Rep. 2016 Feb 02;14(4):823-34
J:243464 Tong X, et al., CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1. PLoS One. 2015;10(10):e0139725
J:244975 Kriebs A, et al., Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8776-8781
J:245577 Tong X, et al., DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver. Diabetes. 2017 Oct;66(10):2571-2582
J:255965 Jordan SD, et al., CRY1/2 Selectively Repress PPARdelta and Limit Exercise Capacity. Cell Metab. 2017 Jul 5;26(1):243-255.e6
J:266073 Toledo M, et al., Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1. Cell Metab. 2018 Aug 7;28(2):268-281.e4
J:268088 Saran AR, et al., JMJD5 links CRY1 function and proteasomal degradation. PLoS Biol. 2018 Nov;16(11):e2006145
J:273529 Wong JCY, et al., Differential roles for cryptochromes in the mammalian retinal clock. FASEB J. 2018 Aug;32(8):4302-4314
J:283196 Hirano A, et al., USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock. PLoS One. 2016;11(4):e0154263