Sequence Detail

ID/Version

P98083 Q8K4C6 Q8K4C7 Q8BFY3 Q3U2Q7 (UniProt | EBI)

Last sequence update: 2002-05-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=SHC-transforming protein 1;AltName: Full=SHC-transforming protein A;AltName: Full=Src homology 2 domain-containing-transforming protein C1; Short=SH2 domain protein C1;

Provider

SWISS-PROT

Sequence

Polypeptide 579 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Shc1	src homology 2 domain-containing transforming protein C1	82	106	3	70

Sequence references in MGI

J:38189 Lioubin MN, et al., p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes Dev. 1996 May 1;10(9):1084-95
J:38190 Damen JE, et al., The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1689-93
J:39401 Blaikie P, et al., A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J Biol Chem. 1994 Dec 23;269(51):32031-4
J:51807 Gu H, et al., Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol Cell. 1998 Dec;2(6):729-40
J:81977 Napoli C, et al., Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2112-6
J:93419 Abou-Rjaily GA, et al., CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation. J Clin Invest. 2004 Nov;114(7):944-52
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:127946 Lucas DM, et al., A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development. Blood. 1999 Mar 15;93(6):1922-33
J:130626 Minichiello L, et al., Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron. 2002 Sep 26;36(1):121-37
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:177164 Vindis C, et al., EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J Cell Biol. 2003 Aug 18;162(4):661-71
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89