Sequence Detail

ID/Version

Q00342 (UniProt | EBI)

Last sequence update: 2015-04-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Receptor-type tyrosine-protein kinase FLT3; EC=2.7.10.1;AltName: Full=FL cytokine receptor;AltName: Full=Fetal liver kinase 2; Short=FLK-2;AltName: Full=Fms-like tyrosine kinase 3; Short=FLT-3;AltName: Full=Tyrosine-p

Provider

SWISS-PROT

Sequence

Polypeptide 1000 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Flt3	FMS-like tyrosine kinase 3	94	121	3	21

Sequence references in MGI

J:1614 Rosnet O, et al., Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene. 1991 Sep;6(9):1641-50
J:11299 Matthews W, et al., A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell. 1991 Jun 28;65(7):1143-52
J:27238 Mackarehtschian K, et al., Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity. 1995 Jul;3(1):147-61
J:56367 Wolf I, et al., Fiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3. J Biol Chem. 1999 Jul 23;274(30):21478-84
J:136209 Waskow C, et al., The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol. 2008 Jun;9(6):676-83
J:140548 Maroc N, et al., Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase. Oncogene. 1993 Apr;8(4):909-18
J:147362 Liu K, et al., In vivo analysis of dendritic cell development and homeostasis. Science. 2009 Apr 17;324(5925):392-7
J:159599 Eidenschenk C, et al., Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9759-64
J:177101 Zheng R, et al., Further activation of FLT3 mutants by FLT3 ligand. Oncogene. 2011 Sep 22;30(38):4004-14
J:213100 Smith CJ, et al., The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. J Cell Sci. 2013 Mar 15;126(Pt 6):1366-80