Sequence Detail

ID/Version

Q00560 G5E8D2 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Interleukin-6 receptor subunit beta {ECO:0000305}; Short=IL-6 receptor subunit beta; Short=IL-6R subunit beta; Short=IL-6R-beta; Short=IL-6RB;AltName: Full=Interleukin-6 signal transducer;AltName: Full=Membran

Provider

SWISS-PROT

Sequence

Polypeptide 917 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il6st	interleukin 6 signal transducer	88	112	3	30

Sequence references in MGI

J:1240 Saito M, et al., Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J Immunol. 1992 Jun 15;148(12):4066-71
J:43735 Starr R, et al., A family of cytokine-inducible inhibitors of signalling. Nature. 1997 Jun 26;387(6636):917-21
J:43853 Kawasaki K, et al., Osteoclasts are present in gp130-deficient mice. Endocrinology. 1997 Nov;138(11):4959-65
J:53000 Tanaka M, et al., Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit. Blood. 1999 Feb 1;93(3):804-15
J:56200 Nakashima K, et al., Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation. J Neurosci. 1999 Jul 1;19(13):5429-34
J:59922 Ohtani T, et al., Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity. 2000 Jan;12(1):95-105
J:75419 Yoshida K, et al., Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):407-11
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:215386 Malsch P, et al., Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression. J Neurosci. 2014 Jul 23;34(30):9845-56
J:219844 Taniguchi K, et al., A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 5;519(7541):57-62
J:228440 Johnson RW, et al., Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone. Bone. 2015 Dec;81:343-51
J:242968 Standal T, et al., gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation. J Endocrinol. 2014 Nov;223(2):181-90
J:242969 Johnson RW, et al., The primary function of gp130 signaling in osteoblasts is to maintain bone formation and strength, rather than promote osteoclast formation. J Bone Miner Res. 2014 Jun;29(6):1492-505
J:250812 Timper K, et al., IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling. Cell Rep. 2017 Apr 11;19(2):267-280
J:260609 Heink S, et al., Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 2017 Jan;18(1):74-85
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89