Sequence Detail

ID/Version

Q01853 Q3TFH9 Q6PI18 Q3TIM2 Q3TXN9 Q8CEG4 Q8BSR6 (UniProt | EBI)

Last sequence update: 2007-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Transitional endoplasmic reticulum ATPase; Short=TER ATPase; EC=3.6.4.6 {ECO:0000250|UniProtKB:P55072};AltName: Full=15S Mg(2+)-ATPase p97 subunit;AltName: Full=Valosin-containing protein; Short=VCP;

Provider

SWISS-PROT

Sequence

Polypeptide 806 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Vcp	valosin containing protein	204	113	3	33

Sequence references in MGI

J:2369 Egerton M, et al., VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation. EMBO J. 1992 Oct;11(10):3533-40
J:88876 Dreveny I, et al., Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47. EMBO J. 2004 Mar 10;23(5):1030-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100999 Giannakopoulos NV, et al., Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem Biophys Res Commun. 2005 Oct 21;336(2):496-506
J:102925 Li G, et al., Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15809-14
J:172993 Li G, et al., The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8348-53
J:192765 Kernstock S, et al., Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Nat Commun. 2012;3:1038
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:208390 Glinka T, et al., Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex. Biochem J. 2014 Jan 15;457(2):253-61
J:215393 Yamamoto S, et al., Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity. Dev Biol. 2014 Sep 1;393(1):33-43
J:240290 DeLaBarre B, et al., Nucleotide dependent motion and mechanism of action of p97/VCP. J Mol Biol. 2005 Mar 25;347(2):437-52
J:274568 Choi JH, et al., LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. Science. 2019 May 10;364(6440)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:341406 Teng Y, et al., UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP. Biochem Pharmacol. 2015 Oct 15;97(4):518-530