Sequence Detail

ID/Version

Q02248 Q9D335 Q922W1 (UniProt | EBI)

Last sequence update: 1993-07-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Catenin beta-1 {ECO:0000312|MGI:MGI:88276};AltName: Full=Beta-catenin {ECO:0000303|PubMed:1509266};

Provider

SWISS-PROT

Sequence

Polypeptide 781 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ctnnb1	catenin beta 1	496	383	4	54

Sequence references in MGI

J:26079 Butz S, et al., Plakoglobin and beta-catenin: distinct but closely related [letter]. Science. 1992 Aug 21;257(5073):1142-4
J:37378 Butz S, et al., Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion. FEBS Lett. 1994 Nov 28;355(2):195-200
J:60324 Kikuchi A, Regulation of beta-catenin signaling in the Wnt pathway. Biochem Biophys Res Commun. 2000 Feb 16;268(2):243-8
J:61504 Pokutta S, et al., Structure of the dimerization and beta-catenin-binding region of alpha-catenin. Mol Cell. 2000 Mar;5(3):533-43
J:85837 Kanamori M, et al., The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J Biol Chem. 2003 Oct 3;278(40):38758-64
J:87181 Gold DA, et al., RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 2003 Dec 18;40(6):1119-31
J:90567 Akiyama H, et al., Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev. 2004 May 1;18(9):1072-87
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114000 Janssens B, et al., alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. J Cell Sci. 2001 Sep;114(Pt 17):3177-88
J:129033 Choi S, et al., The intercalated disc protein, mXinalpha, is capable of interacting with beta-catenin and bundling actin filaments. J Biol Chem. 2007 Dec 7;282(49):36024-36
J:153473 Sun Y, et al., Scribble interacts with beta-catenin to localize synaptic vesicles to synapses. Mol Biol Cell. 2009 Jul;20(14):3390-400
J:154695 Mahmoudi T, et al., The kinase TNIK is an essential activator of Wnt target genes. EMBO J. 2009 Nov 4;28(21):3329-40
J:160348 Zhao J, et al., AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552. Biochem Biophys Res Commun. 2010 Apr 23;395(1):146-51
J:162068 Jho E, et al., A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. Biochem Biophys Res Commun. 1999 Dec 9;266(1):28-35
J:162941 Sokabe T, et al., The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem. 2010 Jun 11;285(24):18749-58
J:163677 Thibeault S, et al., S-nitrosylation of beta-catenin by eNOS-derived NO promotes VEGF-induced endothelial cell permeability. Mol Cell. 2010 Aug 13;39(3):468-76
J:166029 Daniels DL, et al., ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol Cell. 2002 Sep;10(3):573-84
J:169444 Armstrong A, et al., Frizzled3 Is Required for Neurogenesis and Target Innervation during Sympathetic Nervous System Development. J Neurosci. 2011 Feb 16;31(7):2371-81
J:172420 Lancaster MA, et al., Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome. Nat Med. 2011 Jun;17(6):726-31
J:182415 Huber AH, et al., The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell. 2001 May 4;105(3):391-402
J:184685 Wilson CH, et al., Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J. 2012;31(11):2486-97
J:216499 Wang SH, et al., Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. J Neurosci. 2014 Sep 17;34(38):12745-61
J:221949 Jeong BC, et al., Transmembrane protein 64 reciprocally regulates osteoblast and adipocyte differentiation by modulating Wnt/beta-catenin signaling. Bone. 2015 Sep;78:165-73
J:238141 Keil R, et al., Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3. J Invest Dermatol. 2016 Oct;136(10):2022-9
J:248258 Abe K, et al., EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):13-9
J:269496 Koren E, et al., ARTS mediates apoptosis and regeneration of the intestinal stem cell niche. Nat Commun. 2018 Nov 2;9(1):4582
J:274568 Choi JH, et al., LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. Science. 2019 May 10;364(6440)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:294170 Sun X, et al., ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling. Nat Commun. 2020 Jun 12;11(1):2984
J:306577 Sampietro J, et al., Crystal structure of a beta-catenin/BCL9/Tcf4 complex. Mol Cell. 2006 Oct 20;24(2):293-300
J:341423 Feng XY, et al., Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. Eur J Oral Sci. 2018 Feb;126(1):1-12
J:349400 Miyazaki K, et al., Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation. PLoS One. 2016;11(3):e0152206