Sequence Detail

ID/Version

Q03347 O08598 Q9ESB9 Q9ET65 Q62049 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Runt-related transcription factor 1;AltName: Full=Acute myeloid leukemia 1 protein;AltName: Full=Core-binding factor subunit alpha-2; Short=CBF-alpha-2;AltName: Full=Oncogene AML-1;AltName: Full=Polyomavirus enhancer-binding protein

Provider

SWISS-PROT

Sequence

Polypeptide 451 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Runx1	runt related transcription factor 1	87	207	3	71

Sequence references in MGI

J:3972 Bae SC, et al., Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Oncogene. 1993 Mar;8(3):809-14
J:17787 Bae SC, et al., PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials. Mol Cell Biol. 1994 May;14(5):3242-52
J:31130 Okuda T, et al., AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996 Jan 26;84(2):321-30
J:35115 Wang Q, et al., Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3444-9
J:63680 Tsuji K, et al., Identification and expression of a novel 3'-exon of mouse Runx1/Pebp2alphaB/Cbfa2/AML1 gene. Biochem Biophys Res Commun. 2000 Jul 21;274(1):171-6
J:67056 Telfer JC, et al., Expression and function of a stem cell promoter for the murine CBFalpha2 gene: distinct roles and regulation in natural killer and T cell development. Dev Biol. 2001 Jan 15;229(2):363-82
J:68116 Fujita Y, et al., Identification of an Alternatively Spliced Form of the Mouse AML1/RUNX1 Gene Transcript AML1c and Its Expression in Early Hematopoietic Development. Biochem Biophys Res Commun. 2001 Mar 16;281(5):1248-55
J:112873 Aikawa Y, et al., Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J. 2006 Sep 6;25(17):3955-65
J:121433 Ono M, et al., Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature. 2007 Apr 5;446(7136):685-9
J:131081 Setoguchi R, et al., Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science. 2008 Feb 8;319(5864):822-5
J:167439 Lazarevic V, et al., T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgammat. Nat Immunol. 2011 Jan;12(1):96-104
J:195348 Tanaka H, et al., Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus. EMBO J. 2013 Apr 17;32(8):1183-94
J:196248 Paul C, et al., The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation. Cell Death Differ. 2012 May;19(5):900-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89