Sequence Detail

ID/Version

Q04519 Q3UL52 (UniProt | EBI)

Last sequence update: 1996-02-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Sphingomyelin phosphodiesterase; EC=3.1.4.12 {ECO:0000269|PubMed:27435900, ECO:0000269|PubMed:8702487}; EC=3.1.4.3 {ECO:0000250|UniProtKB:P17405};AltName: Full=Acid sphingomyelinase; Short=ASMase;Contains: RecName: F

Provider

SWISS-PROT

Sequence

Polypeptide 627 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Smpd1	sphingomyelin phosphodiesterase 1, acid lysosomal	70	101	3	13

Sequence references in MGI

J:28903 Newrzella D, et al., Molecular cloning of the acid sphingomyelinase of the mouse and the organization and complete nucleotide sequence of the gene. Biol Chem Hoppe Seyler. 1992 Dec;373(12):1233-8
J:35076 Santana P, et al., Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell. 1996 Jul 26;86(2):189-99
J:35194 Schissel SL, et al., Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene. J Biol Chem. 1996 Aug 2;271(31):18431-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107219 Grassme H, et al., Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nat Med. 2003 Mar;9(3):322-30
J:241171 Gorelik A, et al., Crystal structure of mammalian acid sphingomyelinase. Nat Commun. 2016 Jul 20;7:12196
J:326897 Nozaki K, et al., Caspase-7 activates ASM to repair gasdermin and perforin pores. Nature. 2022 Jun;606(7916):960-967