Sequence Detail

ID/Version

Q04735 (UniProt | EBI)

Last sequence update: 1993-10-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Cyclin-dependent kinase 16; EC=2.7.11.22 {ECO:0000269|PubMed:16461345, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:26305884};AltName: Full=CRK5;AltName: Full=Cell division protein kinase 16;AltName: F

Provider

SWISS-PROT

Sequence

Polypeptide 496 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdk16	cyclin dependent kinase 16	42	100	3	13

Sequence references in MGI

J:3108 Okuda T, et al., PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Oncogene. 1992 Nov;7(11):2249-58
J:4073 Ershler M, et al., Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. Gene. 1993 Feb 28;124(2):305-6
J:40934 Sladeczek F, et al., The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins. Mol Gen Genet. 1997 May 20;254(5):571-7
J:173690 Fu WY, et al., Cyclin-dependent kinase 5-dependent phosphorylation of Pctaire1 regulates dendrite development. Neuroscience. 2011 Apr 28;180:353-9
J:183637 Mikolcevic P, et al., Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. Mol Cell Biol. 2012 Feb;32(4):868-79
J:189991 Liu Y, et al., Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis. J Biol Chem. 2006 Apr 14;281(15):9852-8
J:190410 Chen XY, et al., Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells. J Biol Chem. 2012 Aug 31;287(36):30368-75
J:224586 Zi Z, et al., CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse. PLoS Genet. 2015 Aug;11(8):e1005485
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89