Sequence Detail

ID/Version

Q05512 Q6PDR4 Q3T9L3 Q8BR95 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase MARK2; EC=2.7.11.1; EC=2.7.11.26;AltName: Full=ELKL motif kinase 1; Short=EMK-1;AltName: Full=MAP/microtubule affinity-regulating kinase 2;AltName: Full=PAR1 homolog;AltName: Full=PAR1

Provider

SWISS-PROT

Sequence

Polypeptide 776 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mark2	MAP/microtubule affinity regulating kinase 2	85	102	4	117

Sequence references in MGI

J:12907 Inglis JD, et al., Emk, a protein kinase with homologs in yeast maps to mouse chromosome 19. Mamm Genome. 1993;4(7):401-3
J:57958 Bessone S, et al., EMK protein kinase-null mice: dwarfism and hypofertility associated with alterations in the somatotrope and prolactin pathways. Dev Biol. 1999 Oct 1;214(1):87-101
J:68830 Hurov JB, et al., Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase. Mol Cell Biol. 2001 May;21(9):3206-19
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120128 Hurov JB, et al., Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5680-5
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89