Sequence Detail

ID/Version

Q08775 Q08776 Q9JLN0 Q9R0U4 Q9QUQ6 Q9Z2J7 Q9QY29 O35183 (UniProt | EBI)

Last sequence update: 2001-11-02
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Runt-related transcription factor 2 {ECO:0000312|MGI:MGI:99829};AltName: Full=Acute myeloid leukemia 3 protein;AltName: Full=Core-binding factor subunit alpha-1; Short=CBF-alpha-1;AltName: Full=Oncogene AML-3;AltName: Full=Osteoblast

Provider

SWISS-PROT

Sequence

Polypeptide 607 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Runx2	runt related transcription factor 2	124	274	4	36

Sequence references in MGI

J:19080 Ogawa E, et al., Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology. 1993 May;194(1):314-31
J:19082 Ogawa E, et al., PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6859-63
J:40781 Ducy P, et al., Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 1997 May 30;89(5):747-54
J:40783 Komori T, et al., Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 1997 May 30;89(5):755-64
J:42678 Stewart M, et al., Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8646-51
J:49076 Xiao ZS, et al., Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor. Gene. 1998 Jul 3;214(1-2):187-97
J:57466 Fujiwara M, et al., Isolation and characterization of the distal promoter region of mouse Cbfa1. Biochim Biophys Acta. 1999 Sep 3;1446(3):265-72
J:96487 Liu CJ, et al., The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation. J Biol Chem. 2005 Jan 28;280(4):2788-96
J:108965 Jones DC, et al., Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science. 2006 May 26;312(5777):1223-7
J:115876 Dobreva G, et al., SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell. 2006 Jun 2;125(5):971-86
J:162494 Sierra OL, et al., Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3. Mol Endocrinol. 2010 Jul;24(7):1478-97
J:170631 Hisa I, et al., Parathyroid Hormone-responsive Smad3-related Factor, Tmem119, Promotes Osteoblast Differentiation and Interacts with the Bone Morphogenetic Protein-Runx2 Pathway. J Biol Chem. 2011 Mar 18;286(11):9787-96
J:182495 Jensen ED, et al., p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation. J Cell Biochem. 2008 Apr 1;103(5):1438-51
J:186018 Yang S, et al., Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem. 2011 May 27;286(21):19149-58
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:338158 Zhang Y, et al., IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation. Stem Cells. 2022 Nov 29;40(11):1020-1030
J:341423 Feng XY, et al., Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. Eur J Oral Sci. 2018 Feb;126(1):1-12
J:341424 Feng XY, et al., Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture. Eur J Oral Sci. 2013 Oct;121(5):412-20