Sequence Detail

ID/Version

Q0GUM3 Q0GUM2 (UniProt | EBI)

Last sequence update: 2006-10-03
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Interferon-gamma-inducible GTPase 10 {ECO:0000303|PubMed:16959883}; Short=Irgb10 {ECO:0000303|PubMed:16959883}; EC=3.6.5.- {ECO:0000269|PubMed:33469160};

Provider

SWISS-PROT

Sequence

Polypeptide 417 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Pseudogene	Gm12250	predicted gene 12250	22	96	0	2

Sequence references in MGI

J:113755 Bernstein-Hanley I, et al., The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14092-7
J:134525 Coers J, et al., Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. J Immunol. 2008 May 1;180(9):6237-45
J:236523 Man SM, et al., IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes. Cell. 2016 Oct 6;167(2):382-396.e17
J:287363 Briard B, et al., Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection. Nat Microbiol. 2019 Feb;4(2):316-327
J:317923 Haldar AK, et al., IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins. PLoS Pathog. 2013;9(6):e1003414
J:332797 Ha HJ, et al., Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption. Commun Biol. 2021 Jan 19;4(1):92
J:333124 Khaminets A, et al., Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole. Cell Microbiol. 2010 Jul;12(7):939-61
J:333172 Balakrishnan A, et al., Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa. Cell Death Discov. 2018;4:3
J:333980 Christgen S, et al., The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice. Eur J Immunol. 2022 Feb;52(2):285-296