Sequence Detail

ID/Version

Q0ZLH2 (UniProt | EBI)

Last sequence update: 2006-08-22
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Pejvakin {ECO:0000303|PubMed:16804542};AltName: Full=Protein sirtaki {ECO:0000303|PubMed:17329413};

Provider

SWISS-PROT

Sequence

Polypeptide 352 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pjvk	pejvakin	27	96	3	16

Sequence references in MGI

J:111260 Delmaghani S, et al., Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy. Nat Genet. 2006 Jul;38(7):770-8
J:119820 Schwander M, et al., A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci. 2007 Feb 28;27(9):2163-75
J:228036 Delmaghani S, et al., Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes. Cell. 2015 Nov 5;163(4):894-906
J:240546 Kazmierczak M, et al., Pejvakin, a Candidate Stereociliary Rootlet Protein, Regulates Hair Cell Function in a Cell-Autonomous Manner. J Neurosci. 2017 Mar 29;37(13):3447-3464
J:243147 Harris SL, et al., Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice. Neuroscience. 2017 Mar 06;344:380-393
J:273835 Defourny J, et al., Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8010-8017