Sequence Detail

ID/Version

Q1HFZ0 A0PJD6 Q8CDF9 Q91YX9 Q3U972 Q8BPG9 (UniProt | EBI)

Last sequence update: 2007-05-29
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=RNA cytosine C(5)-methyltransferase NSUN2 {ECO:0000305}; EC=2.1.1.- {ECO:0000269|PubMed:22885326, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31287866};AltName: Full=Myc-induced SUN domain-containing

Provider

SWISS-PROT

Sequence

Polypeptide 757 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nsun2	NOL1/NOP2/Sun domain family member 2	36	98	3	21

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:110310 Frye M, et al., The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors. Curr Biol. 2006 May 23;16(10):971-81
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:179810 Blanco S, et al., The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. PLoS Genet. 2011 Dec;7(12):e1002403
J:203322 Hussain S, et al., The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol Cell Biol. 2013 Apr;33(8):1561-70
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:265476 Tuorto F, et al., RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis. Nat Struct Mol Biol. 2012 Sep;19(9):900-5
J:276717 Gkatza NA, et al., Cytosine-5 RNA methylation links protein synthesis to cell metabolism. PLoS Biol. 2019 Jun;17(6):e3000297
J:279950 Shinoda S, et al., Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs. Nucleic Acids Res. 2019 Sep 19;47(16):8734-8745
J:279952 Hussain S, et al., NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs. Cell Rep. 2013 Jul 25;4(2):255-61
J:279955 Van Haute L, et al., NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs. Nucleic Acids Res. 2019 Sep 19;47(16):8720-8733
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89