Sequence Detail

ID/Version

Q2EG98 Q2EG97 Q2EG93 Q2EG96 Q2EG99 E9QPA5 Q7TN87 Q2EG94 Q2EG95 (UniProt | EBI)

Last sequence update: 2025-02-05
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Polycystin-1-like protein 3 {ECO:0000305}; Short=Polycystin-1L3;AltName: Full=PC1-like 3 protein;AltName: Full=Polycystic kidney disease protein 1-like 3;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 2151 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pkd1l3	polycystic kidney disease 1 like 3	33	103	3	10

Sequence references in MGI

J:83807 Li A, et al., Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes. (Erratum: Genomics 2003;82:498-500). Genomics. 2003 Jun;81(6):596-608
J:110462 LopezJimenez ND, et al., Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells. J Neurochem. 2006 Jul;98(1):68-77
J:112032 Huang AL, et al., The cells and logic for mammalian sour taste detection. Nature. 2006 Aug 24;442(7105):934-8
J:164468 Kawaguchi H, et al., Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells. J Biol Chem. 2010 Jun 4;285(23):17277-81
J:165309 Ishimaru Y, et al., Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae. FASEB J. 2010 Oct;24(10):4058-67
J:168530 Nelson TM, et al., Taste function in mice with a targeted mutation of the pkd1l3 gene. Chem Senses. 2010 Sep;35(7):565-77
J:172581 Horio N, et al., Sour Taste Responses in Mice Lacking PKD Channels. PLoS One. 2011;6(5):e20007
J:182388 Ishimaru Y, et al., Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12569-74
J:198096 Ishii S, et al., The response of PKD1L3/PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs. FEBS J. 2012 May;279(10):1857-70
J:257231 Chang RB, et al., A proton current drives action potentials in genetically identified sour taste cells. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22320-5
J:355637 Su Q, et al., Structural basis for Ca(2+) activation of the heteromeric PKD1L3/PKD2L1 channel. Nat Commun. 2021 Aug 11;12(1):4871
J:359371 Inada H, et al., Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1. EMBO Rep. 2008 Jul;9(7):690-7