Sequence Detail

ID/Version

Q2NL51 (UniProt | EBI)

Last sequence update: 2007-03-20
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Glycogen synthase kinase-3 alpha; Short=GSK-3 alpha; EC=2.7.11.26;AltName: Full=Serine/threonine-protein kinase GSK3A; EC=2.7.11.1 {ECO:0000269|PubMed:22539723};

Provider

SWISS-PROT

Sequence

Polypeptide 490 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gsk3a	glycogen synthase kinase 3 alpha	107	116	4	16

Sequence references in MGI

J:98263 McManus EJ, et al., Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J. 2005 Apr 20;24(8):1571-83
J:115106 Beaulieu JM, et al., An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell. 2005 Jul 29;122(2):261-73
J:121428 Garrido JJ, et al., GSK3 alpha and GSK3 beta are necessary for axon formation. FEBS Lett. 2007 Apr 17;581(8):1579-86
J:130033 MacAulay K, et al., Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. Cell Metab. 2007 Oct;6(4):329-37
J:183987 Lin SY, et al., GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science. 2012 Apr 27;336(6080):477-81
J:201566 Maurer U, et al., Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006 Mar 17;21(6):749-60
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89